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Dig Dis 2017;35:282-287

Highlight: Salt Sensitivity A measure of how your blood pressure responds to salt intake

Tirzepatide is a dual-agonist , meaning it works by targeting two hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Retatrutide is a triple-agonist , meaning it targets three hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Glucagon: affects energy use and fat metabolism Early studies show that retatrutide may be more successful than tirzepatide at managing diabetic kidney disease, as well as for weight control, while tirzepatide may be better at managing blood glucose

Another noteworthy study conducted by Xiao et al., who found that in apolipoprotein E-deficient mice fed a high-fat diet, oral administration of CS SeNPs and Na2SeO3 (40 g Se/kg/day) for 10 weeks significantly increased NO levels and decreased the expression of adhesion molecules, thereby alleviating vascular ECD and reducing atherosclerotic lesions (Xiao et al., 2021)